Regulation of PRDX1 peroxidase activity by Pin1

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

RATIONALE Cardiac hypertrophy results from the complex interplay of differentially regulated cascades based on the phosphorylation status of involved signaling molecules. Although numerous critical regulatory kinases and phosphatases have been identified in the myocardium, the intracellular mechanism for temporal regulation of signaling duration and intensity remains obscure. In the nonmyocyte ...

Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.

Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase (PPIase) Pin1 is a negative regulator of Btk, controlling its expression level by reducing its half-life, whereas...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Light-activated deoxyguanosine: photochemical regulation of peroxidase activity.

Photochemical activation of a deoxyribozyme with peroxidase activity was achieved by the synthesis and incorporation of a caged deoxyguanosine.

Salvianolic acid A exhibits anti-tumor activity in nasopharyngeal carcinoma cells through regulation of Pin1

Background: Nasopharyngeal carcinoma (NPC) remains as a devastating malignancy due to a lack of effective therapy for recurrence and metastasis. Salvianolic acid A (SAA), a compound extracted from Salvia miltiorrhiza, possesses a variety of biological properties such as antioxidant, antithrombotic, myocardial ischemia protection and anti-hepatic-fibrosis. However, the effect of SAA on NPC cells...